Gute Bio Group Launches Advanced RO Plant, Expands NMN Applications

Gute Bio Group is an innovative high-tech enterprise with enzyme catalytic technology in the field of synthetic biology as its core and cross-application of multidisciplinary technologies. The company mainly develops biotechnology and industrialization. The company's main products include glutathione (GSH), β-nicotinamide single nucleotide (NMN) and sodium citicotinamide (CDPC). Among them, glutathione and β-nicotinamide single nucleotides rank in the top three in China in the market share, and their products are sold to Europe, the United States, South Korea, India and other parts of the world.

In 2025, Gut Biotech purchased a fully automated reverse osmosis plant with a capacity of 100 tons per hour. For this reverse osmosis system, we use Dow's high-pressure BW30PRO-400 reverse osmosis membrane model, and Shimge brand pumps, and all pipeline valves will be made of unhygienic stainless steel.In April 2025, the installation and commissioning of the plant has been completed and is already in normal operation.

β β-Nicotinamide mononucleotide (NMN) is a key biomolecule that acts primarily as a precursor to NAD+ (nicotinamide adenine dinucleotide). NAD+ is a core coenzyme for cellular energy metabolism and a variety of physiological functions, but with age, the level of NAD+ in the human body decreases significantly, which is closely related to aging and related diseases. Therefore, NMN is considered to have potential applications in the following areas by supplementing NAD+:

1. Anti-aging and prolonging healthy lifespan

Mechanism of action:

NMN promotes DNA repair and delays cell aging by increasing NAD+ levels and activating sirtuins (longevity protein family), especially SIRT1 and SIRT3.Enhances mitochondrial function and reduces oxidative stress and inflammation.Research Evidence:Animal experiments (such as mice) have shown that NMN supplementation can improve metabolic function, delay muscle degeneration, protect the cardiovascular system, and even prolong life.Human clinical trials are ongoing, and preliminary results suggest that it may improve aging-related indicators (e.g., insulin sensitivity, muscle function).

2. Metabolic disease intervention

Application direction:Diabetes: NAD+ is involved in the regulation of glucose metabolism, and NMN may improve insulin resistance and blood sugar control.Obesity: Promotes lipolysis and energy expenditure by activating the AMPK signaling pathway.Clinical Studies:A small human trial in 2021 found that NMN enhanced muscle insulin sensitivity in middle-aged men.

3. Neuroprotection and cognitive function

Potential effects:NAD+ is involved in maintaining neuronal function and DNA repair, and NMN may delay the progression of neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease).In animal experiments, NMN can improve nerve damage and cognitive function after cerebral ischemia.

4. Cardiovascular health

Protection Mechanism:By increasing NAD+ levels, vascular endothelial function is improved and the risk of atherosclerosis is reduced.Animal studies have shown that NMN can alleviate cardiac ischemia-reperfusion injury.

5. Athletic performance and muscle function

Research Progress:NMN may improve exercise tolerance by enhancing mitochondrial energy metabolism (experiments in mice have shown a 30-50% increase in exercise capacity).NMN supplementation for the elderly may delay muscle atrophy and strength decline.